Sang Y, Menegatti M, Brody JA, Wiggins KL, Cooley BC, Kapfer KN, Kangro K, de Laat B, Peyvandi F, Flick MJ, Smith NL, Shapiro AD, Wolberg AS
Plain Language Summary:
Plasmin helps break down blood clots, raising concerns that reducing its activity could increase the risk of dangerous clots. However, this study found no evidence that the loss or suppression of plasminogen and plasmin activity increased venous clot formation in mice or clot risk in humans. The findings may help address safety concerns about treatments that reduce clot breakdown.
