Immunohematology
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Delivering personalized, evidence-based care for complex immunohematologic conditions
Expert Evaluation and Comprehensive Care for Immune Blood Disorders
At Innovative Hematology, our Immunohematology Program provides specialized diagnosis, treatment, and long-term management for children and adults with rare blood disorders caused by immune system dysfunction. Our team combines clinical expertise, multidisciplinary collaboration, and leading-edge research to deliver personalized, evidence-based care for complex immunohematologic conditions.
Whether you have a newly diagnosed condition or require expert consultation for a challenging case, we are committed to partnering with you throughout your care journey.
Specialized Expertise
Our board-certified hematologists have advanced subspecialty expertise in immune-mediated blood disorders and work closely with specialists across multiple disciplines to provide comprehensive evaluation and individualized treatment plans.
We collaborate with experts in:
- Genetics
- Clinical Immunology
- Rheumatology
- Infectious Diseases
- Maternal-Fetal Medicine
- Transfusion Medicine
- Laboratory Hematology
This multidisciplinary approach allows us to accurately diagnose rare conditions, identify underlying causes, and develop treatment strategies tailored to each patient
Conditions We Treat
Our team evaluates and manages a broad range of immune-mediated hematologic disorders, including:
- Immune thrombocytopenia (ITP)
- Autoimmune hemolytic anemia (AIHA)
- Congenital thrombotic thrombocytopenic purpura (cTTP)
- Immune-mediated thrombotic thrombocytopenic purpura (iTTP)
- Complement-mediated thrombotic microangiopathy (CM-TMA; formerly atypical hemolytic uremic syndrome)
- Evans syndrome
- Autoimmune neutropenia
- Immune-mediated cytopenias
- Other rare immune disorders affecting blood cells and coagulation
Multidisciplinary Care
Living with a rare blood disorder often requires more than medical treatment alone. Our comprehensive care model brings together experts who address the physical, emotional, and practical aspects of living with chronic disease.
Our multidisciplinary team includes:
- Genetic counselors
- Nurse coordinators
- Clinical pharmacists
- Registered dietitians
- Physical therapists
- Dental professionals
- Social workers
- Mental health and psychosocial support services
Together, we provide coordinated care that supports patients and families at every stage of treatment.
Research and Innovation
Innovative Hematology is committed to advancing the understanding and treatment of immune blood disorders.
Our physicians collaborate with national and international experts, participate in multicenter clinical research, and contribute to the development of evidence-based treatment guidelines. Patients may have opportunities to participate in clinical research and observational studies aimed at improving diagnosis, treatment, and long-term outcomes for these rare conditions.
Understanding Immunohematologic Disorders
Immunohematologic disorders occur when the immune system mistakenly attacks healthy blood cells or proteins involved in normal blood clotting. These conditions may develop without an identifiable cause (primary autoimmune disorders) or occur secondary to infections, autoimmune diseases, medications, cancers, or inherited genetic conditions. Accurate diagnosis is essential because many disorders have similar presentations but require very different treatments.
Immune Thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder in which the immune system destroys platelets, resulting in thrombocytopenia (low platelet counts). Individuals may experience easy bruising, petechiae (small red or purple spots), nosebleeds, gum bleeding, heavy menstrual bleeding, or, in some cases, no symptoms at all, with the condition discovered during routine laboratory testing.
Because several inherited platelet disorders and congenital thrombocytopenia syndromes can mimic ITP, careful evaluation is essential to establish the correct diagnosis.
Treatment is individualized based on bleeding symptoms, platelet count, age, lifestyle, and underlying causes. Options may include:
- Observation when appropriate
- Corticosteroids
- Intravenous immunoglobulin (IVIG)
- Thrombopoietin receptor agonists
- Immunomodulatory therapies
- Other targeted treatments for refractory disease
Autoimmune Hemolytic Anemia (AIHA)
Autoimmune hemolytic anemia (AIHA) occurs when the immune system destroys red blood cells faster than the body can replace them, leading to anemia.
Common symptoms include:
- Fatigue
- Shortness of breath
- Rapid heartbeat
- Jaundice
- Dark or cola-colored urine
Treatment focuses on controlling immune-mediated red blood cell destruction while supporting blood production and treating any underlying condition. Depending on disease severity, therapy may include immunosuppressive medications, targeted therapies, blood transfusions, or supportive care.
Thrombotic Microangiopathies (TMA)
Thrombotic microangiopathies (TMAs) are rare but potentially life-threatening disorders characterized by the formation of microscopic blood clots within small blood vessels throughout the body.
These clots consume platelets, resulting in thrombocytopenia, and damage red blood cells as they pass through affected vessels, leading to hemolytic anemia. TMAs can also cause injury to vital organs, including the brain, kidneys, and heart, making prompt diagnosis and treatment essential.
Conditions within this group include:
- Congenital thrombotic thrombocytopenic purpura (cTTP): An inherited disorder caused by severe deficiency of the ADAMTS13 enzyme.
- Immune-mediated thrombotic thrombocytopenic purpura (iTTP): An autoimmune condition in which antibodies inhibit ADAMTS13 activity, leading to widespread clot formation.
- Complement-mediated thrombotic microangiopathy (CM-TMA): A disorder caused by dysregulation of the complement system, previously referred to as atypical hemolytic uremic syndrome (aHUS).
Our team provides rapid diagnostic evaluation and evidence-based treatment using the latest therapeutic approaches, including plasma exchange, immunosuppressive therapies, complement inhibitors, and other targeted treatments when appropriate.
Why Choose Innovative Hematology
- Expert care from nationally recognized specialists in benign hematology and rare blood disorders
- Comprehensive evaluation using advanced laboratory testing and genetic diagnostics
- Multidisciplinary care tailored to each patient’s unique needs
- Access to clinical trials and emerging therapies
- Care across the lifespan, serving both pediatric and adult patients
- National leadership in research, education, and the development of evidence-based clinical care
At Innovative Hematology, we are redefining the care of rare immune-mediated blood disorders through a commitment to clinical excellence, innovation, and compassionate, patient-centered care. Our patients have access to the latest advances in precision medicine, including state-of-the-art therapies, novel clinical trials, and comprehensive genomic and molecular diagnostics that enable highly personalized treatment strategies. By integrating expert multidisciplinary care with cutting-edge research, we are improving outcomes, expanding therapeutic possibilities, and helping shape the future of immunohematology.
"The staff is amazing. Especially when you are a new patient. I felt like I was at home and people really cared."
"We're thrilled to be at a practice that values the details of patient care--even after we walk out the door. It's such a relief to know that the staff follows through."
"IHTC has been incredibly supportive, and I cannot imagine my hemophilia care without IHTC."
"The staff at IHTC have always been kind and courteous in all their interactions with me. My questions and concerns are always answered promptly and correctly."
"This practice has to be one of the best I have ever encountered in my 75 years. They are proactive. I have been treated with kindness, respect, and dignity."
"Been a patient for more than twenty years. I have always been treated well by everyone in the office."
"The center has checked all the boxes when it comes to providing proficient medical care."