Plain Language Summary: Type 1 plasminogen deficiency (PLGD) is an ultra-rare genetic disorder that can cause harmful fibrin-rich lesions on the body’s mucous membranes, affecting organs and quality of life. Because symptoms often resemble more common conditions, diagnosis is frequently delayed. This article highlights the importance of recognizing PLGD early, confirming the diagnosis through testing, and providing ongoing specialized care. Treatment with IV plasminogen concentrate can help control or prevent lesions, with therapy tailored to each patient’s needs and disease severity.
